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Laboratory
News & Journal Club
![[Journal clubs] Jul 16, 2026 [Stem-like PD-1+TCF-1+ CD8+ T cells result from helpless priming and rely on CD4+ T-cell help to complete their cytotoxic effector differentiation]](https://static.wixstatic.com/media/9cf8ca_e635e2e659ab4a0abbb89e1447f98657~mv2.png/v1/fill/w_1006,h_752,fp_0.50_0.50,q_35,blur_30,enc_avif,quality_auto/9cf8ca_e635e2e659ab4a0abbb89e1447f98657~mv2.png)
![[Journal clubs] Jul 16, 2026 [Stem-like PD-1+TCF-1+ CD8+ T cells result from helpless priming and rely on CD4+ T-cell help to complete their cytotoxic effector differentiation]](https://static.wixstatic.com/media/9cf8ca_e635e2e659ab4a0abbb89e1447f98657~mv2.png/v1/fill/w_1006,h_752,fp_0.50_0.50,q_95,enc_avif,quality_auto/9cf8ca_e635e2e659ab4a0abbb89e1447f98657~mv2.png)
[Journal clubs] Jul 16, 2026 [Stem-like PD-1+TCF-1+ CD8+ T cells result from helpless priming and rely on CD4+ T-cell help to complete their cytotoxic effector differentiation]
Busselaar J, Bosma DMT, Staal MD, Lei X, Xiao Y, Borst J. Stem-like PD-1+TCF-1+ CD8+ T cells result from helpless priming and rely on CD4+ T-cell help to complete their cytotoxic effector differentiation. Journal for ImmunoTherapy of Cancer. 2026;14:e014041. https://doi.org/10.1136/jitc-2025-014041 발표일자: 2026.07.16. 발표자: 안세람
![[Journal clubs] Jul 9, 2026 [Predicting transcriptional outcomes of novel multigene perturbations with GEARS]](https://static.wixstatic.com/media/9cf8ca_551dff55d4ac45778cdf450723d9f2e8~mv2.png/v1/fill/w_1338,h_1000,fp_0.50_0.50,q_35,blur_30,enc_avif,quality_auto/9cf8ca_551dff55d4ac45778cdf450723d9f2e8~mv2.png)
![[Journal clubs] Jul 9, 2026 [Predicting transcriptional outcomes of novel multigene perturbations with GEARS]](https://static.wixstatic.com/media/9cf8ca_551dff55d4ac45778cdf450723d9f2e8~mv2.png/v1/fill/w_1188,h_888,fp_0.50_0.50,q_95,enc_avif,quality_auto/9cf8ca_551dff55d4ac45778cdf450723d9f2e8~mv2.png)
[Journal clubs] Jul 9, 2026 [Predicting transcriptional outcomes of novel multigene perturbations with GEARS]
Roohani, Y., Huang, K. & Leskovec, J. Predicting transcriptional outcomes of novel multigene perturbations with GEARS. Nat Biotechnol 42, 927–935 (2024). https://doi.org/10.1038/s41587-023-01905-6 발표일자: 2026.07.09. 발표자: 장현빈
![[Journal clubs] Jul 2, 2026 [Single-cell meta-analyses reveal responses of tumor-reactive CXCL13+ T cells to immune-checkpoint blockade | Nature Cancer]](https://static.wixstatic.com/media/9cf8ca_aa8981b86109462791bd4816949bdb45~mv2.png/v1/fill/w_1333,h_1000,fp_0.50_0.50,q_35,blur_30,enc_avif,quality_auto/9cf8ca_aa8981b86109462791bd4816949bdb45~mv2.png)
![[Journal clubs] Jul 2, 2026 [Single-cell meta-analyses reveal responses of tumor-reactive CXCL13+ T cells to immune-checkpoint blockade | Nature Cancer]](https://static.wixstatic.com/media/9cf8ca_aa8981b86109462791bd4816949bdb45~mv2.png/v1/fill/w_1184,h_888,fp_0.50_0.50,q_95,enc_avif,quality_auto/9cf8ca_aa8981b86109462791bd4816949bdb45~mv2.png)
[Journal clubs] Jul 2, 2026 [Single-cell meta-analyses reveal responses of tumor-reactive CXCL13+ T cells to immune-checkpoint blockade | Nature Cancer]
Liu, B., Zhang, Y., Wang, D., Hu, X., & Zhang, Z. (2022). Single-cell meta-analyses reveal responses of tumor-reactive CXCL13+ T cells to immune-checkpoint blockade. Nature cancer, 3(9), 1123–1136. https://doi.org/10.1038/s43018-022-00433-7 발표일자: 2026.07.02. 발표자: 최화진
![[Journal clubs] May 21, 2026 [Agentic AI and the rise of in silico team science in biomedical research]](https://static.wixstatic.com/media/9cf8ca_e1da8b2e72df42b993c77d65c407e6b8~mv2.png/v1/fill/w_1338,h_1000,fp_0.50_0.50,q_35,blur_30,enc_avif,quality_auto/9cf8ca_e1da8b2e72df42b993c77d65c407e6b8~mv2.png)
![[Journal clubs] May 21, 2026 [Agentic AI and the rise of in silico team science in biomedical research]](https://static.wixstatic.com/media/9cf8ca_e1da8b2e72df42b993c77d65c407e6b8~mv2.png/v1/fill/w_1188,h_888,fp_0.50_0.50,q_95,enc_avif,quality_auto/9cf8ca_e1da8b2e72df42b993c77d65c407e6b8~mv2.png)
[Journal clubs] May 21, 2026 [Agentic AI and the rise of in silico team science in biomedical research]
Li, B., Saini, A.K., Hernandez, J.G. et al. Agentic AI and the rise of in silico team science in biomedical research. Nat Biotechnol 44, 711–725 (2026). https://doi.org/10.1038/s41587-026-03035-1 발표일자: 2026.05.21. 발표자: 송우현
![[Journal clubs] May 14, 2026 [Foundation Models for Biology: V-JEPA2.1, Nicheformer, and Geneformer2]](https://static.wixstatic.com/media/9cf8ca_0ac0d073e50a4db6b689d269db2c827c~mv2.png/v1/fill/w_1338,h_1000,fp_0.50_0.50,q_35,blur_30,enc_avif,quality_auto/9cf8ca_0ac0d073e50a4db6b689d269db2c827c~mv2.png)
![[Journal clubs] May 14, 2026 [Foundation Models for Biology: V-JEPA2.1, Nicheformer, and Geneformer2]](https://static.wixstatic.com/media/9cf8ca_0ac0d073e50a4db6b689d269db2c827c~mv2.png/v1/fill/w_1188,h_888,fp_0.50_0.50,q_95,enc_avif,quality_auto/9cf8ca_0ac0d073e50a4db6b689d269db2c827c~mv2.png)
[Journal clubs] May 14, 2026 [Foundation Models for Biology: V-JEPA2.1, Nicheformer, and Geneformer2]
V-JEPA2.1 Mur-Labadia, Lorenzo, et al. "V-jepa 2.1: Unlocking dense features in video self-supervised learning." arXiv preprint arXiv:2603.14482 (2026). Nicheformer Tejada-Lapuerta, A., Schaar, A.C., Gutgesell, R. et al. Nicheformer: a foundation model for single-cell and spatial omics. Nat Methods 22, 2525–2538 (2025). https://doi.org/10.1038/s41592-025-02814-z Geneformer2 Chen, H., Venkatesh, M.S., Gόmez Ortega, J. et al. Scaling and quantization of large-scale foundation
![[Journal clubs] Apr 30, 2026 [Stress-induced sympathetic hyperactivation drives hair follicle necrosis to trigger autoimmunity]](https://static.wixstatic.com/media/9cf8ca_30d05c4f5927498cac71d9ea5bc56817~mv2.png/v1/fill/w_996,h_747,fp_0.50_0.50,q_35,blur_30,enc_avif,quality_auto/9cf8ca_30d05c4f5927498cac71d9ea5bc56817~mv2.png)
![[Journal clubs] Apr 30, 2026 [Stress-induced sympathetic hyperactivation drives hair follicle necrosis to trigger autoimmunity]](https://static.wixstatic.com/media/9cf8ca_30d05c4f5927498cac71d9ea5bc56817~mv2.png/v1/fill/w_996,h_747,fp_0.50_0.50,q_95,enc_avif,quality_auto/9cf8ca_30d05c4f5927498cac71d9ea5bc56817~mv2.png)
[Journal clubs] Apr 30, 2026 [Stress-induced sympathetic hyperactivation drives hair follicle necrosis to trigger autoimmunity]
Scott-Solomon E, Brielle S, Mann A. Stress-induced sympathetic hyperactivation drives hair follicle necrosis to trigger autoimmunity Cell, 2025; 189, 252-271.e19 DOI: 10.1016/j.cell.2025.10.042 발표일자: 2026.04.30. 발표자: 조유빈
![[Journal clubs] Mar 19, 2026 [A glucocorticoid–FAS axis controls immune evasion during metastatic seeding]](https://static.wixstatic.com/media/9cf8ca_9785c990d02a4483adb961f7d5f31968~mv2.png/v1/fill/w_1338,h_1000,fp_0.50_0.50,q_35,blur_30,enc_avif,quality_auto/9cf8ca_9785c990d02a4483adb961f7d5f31968~mv2.png)
![[Journal clubs] Mar 19, 2026 [A glucocorticoid–FAS axis controls immune evasion during metastatic seeding]](https://static.wixstatic.com/media/9cf8ca_9785c990d02a4483adb961f7d5f31968~mv2.png/v1/fill/w_1188,h_888,fp_0.50_0.50,q_95,enc_avif,quality_auto/9cf8ca_9785c990d02a4483adb961f7d5f31968~mv2.png)
[Journal clubs] Mar 19, 2026 [A glucocorticoid–FAS axis controls immune evasion during metastatic seeding]
Cassandras, M., Sanchez, X., Hsu, L. et al. A glucocorticoid–FAS axis controls immune evasion during metastatic seeding. Nature 653, 567–575 (2026). https://doi.org/10.1038/s41586-026-10222-2 발표일자: 2026.03.19. 발표자: 최화진
![[Journal clubs] Mar 05, 2026 [Memory CD8 T cells are vulnerable to chronic IFN-γ signals but not to CD4 T cell deficiency in MHCII-deficient mice]](https://static.wixstatic.com/media/9cf8ca_317ff6073e514e6091183c6a7c67aa6e~mv2.png/v1/fill/w_1338,h_1000,fp_0.50_0.50,q_35,blur_30,enc_avif,quality_auto/9cf8ca_317ff6073e514e6091183c6a7c67aa6e~mv2.png)
![[Journal clubs] Mar 05, 2026 [Memory CD8 T cells are vulnerable to chronic IFN-γ signals but not to CD4 T cell deficiency in MHCII-deficient mice]](https://static.wixstatic.com/media/9cf8ca_317ff6073e514e6091183c6a7c67aa6e~mv2.png/v1/fill/w_1188,h_888,fp_0.50_0.50,q_95,enc_avif,quality_auto/9cf8ca_317ff6073e514e6091183c6a7c67aa6e~mv2.png)
[Journal clubs] Mar 05, 2026 [Memory CD8 T cells are vulnerable to chronic IFN-γ signals but not to CD4 T cell deficiency in MHCII-deficient mice]
Setoguchi, R., Sengiku, T., Kono, H. et al. Memory CD8 T cells are vulnerable to chronic IFN-γ signals but not to CD4 T cell deficiency in MHCII-deficient mice. Nat Commun 15, 4418 (2024). https://doi.org/10.1038/s41467-024-48704-4 발표일자: 2026.03.05. 발표자: 안세람
![[Journal clubs] Feb 19, 2026 [Metabolic characterization of tumor-immune interactions by multiplexed immunofluorescence reveals spatial mechanisms of immunotherapy response in non-small cell lung car]](https://static.wixstatic.com/media/9cf8ca_fe0a18341dba4d2a80d993fe182bee9c~mv2.png/v1/fill/w_1333,h_1000,fp_0.50_0.50,q_35,blur_30,enc_avif,quality_auto/9cf8ca_fe0a18341dba4d2a80d993fe182bee9c~mv2.png)
![[Journal clubs] Feb 19, 2026 [Metabolic characterization of tumor-immune interactions by multiplexed immunofluorescence reveals spatial mechanisms of immunotherapy response in non-small cell lung car]](https://static.wixstatic.com/media/9cf8ca_fe0a18341dba4d2a80d993fe182bee9c~mv2.png/v1/fill/w_1184,h_888,fp_0.50_0.50,q_95,enc_avif,quality_auto/9cf8ca_fe0a18341dba4d2a80d993fe182bee9c~mv2.png)
[Journal clubs] Feb 19, 2026 [Metabolic characterization of tumor-immune interactions by multiplexed immunofluorescence reveals spatial mechanisms of immunotherapy response in non-small cell lung car]
Monkman, J., Kilgallon, A., Lawler, C. et al. Metabolic characterization of tumor-immune interactions by multiplexed immunofluorescence reveals spatial mechanisms of immunotherapy response in non-small cell lung carcinoma (NSCLC). Nat Commun 17, 837 (2026). https://doi.org/10.1038/s41467-026-68633-8 발표일자: 2026.02.19. 발표자: 윤성민
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